According to the characteristics of the spray dryer; the characteristics of the pharmaceutical materials; and the GMP requirements for the equipment are comprehensively considered, for most materials:
A. Model: It adopts open circulation, vertical descending and co-current type. It is recommended to use high-speed centrifugal rotary disc spray dryer, especially for traditional Chinese medicine. If the particle size of dry powder is required to be more than 100 mesh (150 μm), a pressure nozzle spray dryer can be selected.
B. The basic functions that the equipment should have:
1. In order to ensure that the dried products are not polluted, all the materials in contact with the materials and hot air are made of stainless steel, and the stainless steel grades should be adapted to the pH value of the pharmaceutical materials.
2. In order to meet the sanitation requirements, the air entering the tower must be sterilized and filtered, and the purification degree can be considered as 100,000... The drying tower should be operated under slightly positive pressure. The finished product is output at the lower part of the drying tower cone, and the finished product is collected and packaged in the clean room.
3. In order to ensure that the emission concentration of tail gas meets the requirements of environmental protection, two-stage dust removal should be considered. The first stage is used for dry powder recovery by high-efficiency cyclone separator, and the second stage can be used for dry bag filter or wet dust collector for tail powder recovery. For dryers with strong hygroscopicity and multi-variety production, wet dust collectors are more suitable.
4. The equipment itself has good airtightness, no pollution source and material contact, the inner wall is smooth and smooth, the structure is simplified as much as possible, easy to disassemble, easy to clean, and stable in operation.
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